ME/CFS Part 2: Etiology and Analeptic Management

Presented by Todd E. Davenport, Mark VanNess, and Staci Stevens

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This lesson is the second part of the two-course series. Complete Part One before beginning this course.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) causes severely disabling fatigue within the context of a constellation of unusual signs and symptoms, which are associated with overexertion. Because people with ME/CFS present with a whole host of clinical findings, there are multiple reasons for entry into medical and rehabilitation settings. The multifactorial clinical presentation of ME/CFS emphasizes the need for clinicians to recognize ME/CFS, in order to advocate for patients/clients with possible ME/CFS and to direct its appropriate management. The pathoetiology of ME/CFS is becoming better understood, and there is emerging evidence based on this pathoetiological evidence to support best practices in analeptic management strategies for people with ME/CFS.

This two-part course series provides the opportunity for attendees to receive the latest information in recognition, etiology, and analeptic management of patients with ME/CFS from a panel of established researchers and clinicians. In this session, the presenters will (i) summarize the clinical features ME/CFS with respect to optimal identification and differential diagnosis; (ii) describe the pathoetiology underlying the clinical features of ME/CFS; and (iii) provide an actionable framework for optimal analeptic management of individuals with ME/CFS that is based on current scientific evidence.

Meet your instructors

Todd E. Davenport

Todd serves as professor and vice-chair of the Department of Physical Therapy in the School of Health Sciences at the University of the Pacific in Stockton, California, where he teaches in the Doctor of Physical Therapy (DPT) program. Todd is a graduate of the University of Southern California’s DPT and Orthopedic Physical…

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Mark VanNess

J. Mark VanNess, PhD, is a cardiovascular biologist and Distinguished Professor in the department of Health and Exercise Science at the University of the Pacific. He studied biology, chemistry, and exercise science as an undergraduate student and exercise physiology for his master’s degree. He received his doctoral degree…

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Staci Stevens

Staci Stevens holds a bachelor's degree in Sports Medicine and a master's degree in Exercise Physiology from the University of the Pacific in Stockton, California. Ms. Stevens, in conjunction with Workwell Foundation’s research team, pioneered the use of two-day cardiopulmonary exercise testing (CPET) in myalgic…

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Chapters & learning objectives

Etiological Clues From Cardiopulonary Exercise Testing

1. Etiological Clues From Cardiopulonary Exercise Testing

Measurements obtained during maximal cardiopulmonary exercise tests (CPET) are commonly used across clinical populations to make determinations regarding cardiac, pulmonary, and metabolic deficits that may underlie disablement, as well as to stratify the severity of functional impairment. Similarly, maximal CPET has been used in people with ME/CFS. The purpose of this chapter is to introduce the learner to inferences that can be made regarding the pathoetiology of disablement in ME/CFS, based on maximal CPET data.

Analeptic Strategies for ME/CFS

2. Analeptic Strategies for ME/CFS

Clinical management strategies for ME/CFS should be informed by current physiological evidence. Specifically, CPET findings of aerobic system dysfunction suggest that clinical management should emphasize energy conservation self-management strategies and restorative anaerobic activities, as tolerated by the patient. The purpose of this chapter is to describe a staged approach to analeptic management for people with ME/CFS.