Tissue Injury: Mechanisms of Inflammation and Repair
Presented by Andrew J. Opett
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This course provides an overview of the inflammatory process and the process of tissue repair following injury. The three distinct phases of inflammation and tissue repair will be discussed. The major chemical mediators of inflammation and their effects will be covered. The inflammation and tissue healing process in specific musculoskeletal tissues, including bone, muscle, tendon, ligament, and cartilage, will be discussed.
Meet your instructor
Andrew J. Opett
Andrew Opett received a bachelor of science degree in biology from the State University of New York at Geneseo in 1996; a bachelor of science degree in health sciences from Nazareth College of Rochester, New York, in 2000; and a master of science degree in physical therapy from Nazareth College of Rochester, New York, in…
Chapters & learning objectives
1. Injury and Inflammation
This chapter will cover the process of inflammation, which is a necessary stage in tissue healing and repair. The cardinal signs of inflammation and the mechanisms behind their occurrence will be explained.
2. Chemical Mediators of the Inflammatory Process
This chapter will investigate more closely the chemical substances that are involved with the inflammatory process. The derivations of these chemical mediators will be discussed in order to better understand their function and how they contribute to the overall healing process following tissue injury. The relationship between chemical mediators of inflammation and the mechanism of action of the anti-inflammatory medications, including NSAIDs and corticosteroids, will be discussed. The difference between acute and chronic inflammation will also be discussed.
3. Proliferation and Maturation Phases of Tissue Healing: Epithelial Tissues
This chapter will look more closely at the proliferation and maturation phases of wound healing and repair in epithelial tissues. The key events in each of these stages will be discussed.
4. Proliferation and Maturation Phases of Tissue Healing: Musculoskeletal Tissues
This chapter will look more closely at the proliferation and maturation phases of wound healing and tissue repair for musculoskeletal tissues, including bone, tendon, ligament, muscle, and cartilage. Healing potential and healing times for each of these connective and muscular tissues will be discussed.
